Compile Data Set for Download or QSAR
maximum 50k data
Found 1401 of ic50 data for polymerid = 50001338,50002198,50007583
TargetAldo-keto reductase family 1 member B1(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50009832(1-Benzyl-4-hydroxy-5-oxo-2,5-dihydro-1H-pyrrole-3-...)
Affinity DataIC50:  0.420nMAssay Description:Inhibitory activity was measured against rat lens aldose reductase in the presence of 1 uM compound with D-glucose as substratesChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50009832(1-Benzyl-4-hydroxy-5-oxo-2,5-dihydro-1H-pyrrole-3-...)
Affinity DataIC50:  0.420nMAssay Description:Inhibitory activity was measured against rat lens aldose reductase in the presence of 1 uM compound with D-glucose as substratesChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50487936(CHEBI:48480 | CHEMBL2261578)
Affinity DataIC50:  1.30nMAssay Description:Inhibition of Rattus norvegicus (rat) lens aldose reductaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetAldo-keto reductase family 1 member B1(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM16314(2-{[6-methoxy-5-(trifluoromethyl)naphthalen-1-yl]-...)
Affinity DataIC50:  2nMAssay Description:In vitro inhibitory activity against L-Hexonate Dehydrogenase (L-HDH) from rat kidney (RK)More data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member B1(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50122956(CHEMBL138065 | [2,4-Bis-(4-methoxy-benzoyl)-pyrrol...)
Affinity DataIC50:  2.36nMAssay Description:Inhibitory activity against aldose reductase enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50122956(CHEMBL138065 | [2,4-Bis-(4-methoxy-benzoyl)-pyrrol...)
Affinity DataIC50:  2.40nMAssay Description:Inhibition of ALR in Fischer-344 rat lens using D,L-glyceraldehyde as substrate in presence of NADPH measured after 3 mins by spectrophotometric assa...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetAldo-keto reductase family 1 member B1(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM16314(2-{[6-methoxy-5-(trifluoromethyl)naphthalen-1-yl]-...)
Affinity DataIC50:  3nMAssay Description:Inhibitory activity measured against rat lens aldose reductase using 3-pyridinecarboxaldehyde as substrateChecked by AuthorMore data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member B1(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50487916(CHEMBL2261575)
Affinity DataIC50:  4.20nMAssay Description:Inhibition of Rattus norvegicus (rat) lens aldose reductaseMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
TargetAldo-keto reductase family 1 member B1(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM16496(2-{3-[(4-bromo-2-fluorophenyl)methyl]-7-chloro-2,4...)
Affinity DataIC50:  4.40nMAssay Description:Inhibitory activity against purified rat lens aldose reductase (RLAR)More data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member B1(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM16452((4-oxo-3-{[5-(trifluoromethyl)-1,3-benzothiazol-2-...)
Affinity DataIC50:  5nMAssay Description:Inhibition of Wistar rat lens aldose reductase 2More data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member B1(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50010283(2,7-difluorospiro[9H-fluorene-9,4'-(tetrahydro-1'H...)
Affinity DataIC50:  5nMAssay Description:In vitro inhibitory activity against L-Hexonate Dehydrogenase (L-HDH) from rat kidney (RK)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM16452((4-oxo-3-{[5-(trifluoromethyl)-1,3-benzothiazol-2-...)
Affinity DataIC50:  5nMAssay Description:Inhibition of Wistar rat lens aldose reductase using D,L-glyceraldehyde as substrate incubated for 1 min measured for 4 mins by spectrophotometryMore data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member B1(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50010282(2,7-difluorospiro[9H-fluorene-9,3'-(tetrahydro-1'H...)
Affinity DataIC50:  5nMAssay Description:In vitro inhibitory activity against Aldose reductase from rat lensMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM16469(2-{3-[(4,5,7-trifluoro-1,3-benzothiazol-2-yl)methy...)
Affinity DataIC50:  5nMAssay Description:Inhibition of Wistar rat lens aldose reductase using D,L-glyceraldehyde as substrate incubated for 1 min measured for 4 mins by spectrophotometryMore data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member B1(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50056538(CHEMBL159820 | [3-(5-Chloro-benzothiazol-2-ylmethy...)
Affinity DataIC50:  5.70nMAssay Description:Inhibitory activity against rat lens aldose reductase(AR).More data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member B1(Sus scrofa)
TBA

Curated by ChEMBL
LigandPNGBDBM50289610(CHEMBL44717 | [3-(4,5,7-Trifluoro-benzothiazol-2-y...)
Affinity DataIC50:  6.60nMAssay Description:Inhibitory concentration against porcine lens aldose reductase (AR) with DL-glyceraldehyde as the substrateMore data for this Ligand-Target Pair
In DepthDetails Article
TargetAldo-keto reductase family 1 member B1(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50563402(CHEMBL4782479)
Affinity DataIC50:  6.90nMAssay Description:Inhibition of Wistar rat lens ALR2 assessed as reduction in NADPH oxidation using D,L-glyceraldehyde and NADPH as substrate preincubated for 10 mins ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Sus scrofa)
TBA

Curated by ChEMBL
LigandPNGBDBM50289614(CHEMBL288748 | [3-Chloro-5-(4,5,7-trifluoro-benzot...)
Affinity DataIC50:  7nMAssay Description:Inhibitory concentration against porcine lens aldose reductase (AR) with DL-glyceraldehyde as the substrateMore data for this Ligand-Target Pair
In DepthDetails Article
TargetAldo-keto reductase family 1 member B1(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50487917(CHEMBL2261574)
Affinity DataIC50:  8.10nMAssay Description:Inhibition of Rattus norvegicus (rat) lens aldose reductaseMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
TargetAldo-keto reductase family 1 member B1(Sus scrofa)
TBA

Curated by ChEMBL
LigandPNGBDBM50289613(CHEMBL44743 | {Phenyl-[3-(4,5,7-trifluoro-benzothi...)
Affinity DataIC50:  8.30nMAssay Description:Inhibitory concentration against porcine lens aldose reductase (AR) with DL-glyceraldehyde as the substrateMore data for this Ligand-Target Pair
In DepthDetails Article
TargetAldo-keto reductase family 1 member B1(Sus scrofa)
TBA

Curated by ChEMBL
LigandPNGBDBM50289624(CHEMBL44780 | {Phenyl-[3-(4,5,7-trifluoro-benzothi...)
Affinity DataIC50:  8.40nMAssay Description:Inhibitory concentration against porcine lens aldose reductase (AR) with DL-glyceraldehyde as the substrateMore data for this Ligand-Target Pair
In DepthDetails Article
TargetAldo-keto reductase family 1 member B1(Sus scrofa)
TBA

Curated by ChEMBL
LigandPNGBDBM50289628(3-Carboxymethyl-5-(4,5,7-trifluoro-benzothiazol-2-...)
Affinity DataIC50:  8.70nMAssay Description:Inhibitory concentration against porcine lens aldose reductase (AR) with DL-glyceraldehyde as the substrateMore data for this Ligand-Target Pair
In DepthDetails Article
TargetAldo-keto reductase family 1 member B1(Sus scrofa)
TBA

Curated by ChEMBL
LigandPNGBDBM50289617(CHEMBL47614 | [3-Fluoro-5-(4,5,7-trifluoro-benzoth...)
Affinity DataIC50:  8.80nMAssay Description:Inhibitory concentration against porcine lens aldose reductase (AR) with DL-glyceraldehyde as the substrateMore data for this Ligand-Target Pair
In DepthDetails Article
TargetAldo-keto reductase family 1 member B1(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50010283(2,7-difluorospiro[9H-fluorene-9,4'-(tetrahydro-1'H...)
Affinity DataIC50:  9nMAssay Description:In vitro inhibition of Aldose reductase (AR) from rat lens (RL)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50010282(2,7-difluorospiro[9H-fluorene-9,3'-(tetrahydro-1'H...)
Affinity DataIC50:  9nMAssay Description:In vitro inhibitory activity against L-Hexonate Dehydrogenase (L-HDH) from rat kidney (RK)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Sus scrofa)
TBA

Curated by ChEMBL
LigandPNGBDBM50289616(CHEMBL45751 | [2-Chloro-3-(4,5,7-trifluoro-benzoth...)
Affinity DataIC50:  9.30nMAssay Description:Inhibitory concentration against porcine lens aldose reductase (AR) with DL-glyceraldehyde as the substrateMore data for this Ligand-Target Pair
In DepthDetails Article
TargetAldo-keto reductase family 1 member B1(Sus scrofa)
TBA

Curated by ChEMBL
LigandPNGBDBM50289621(CHEMBL46074 | [3-Bromo-5-(4,5,7-trifluoro-benzothi...)
Affinity DataIC50:  9.40nMAssay Description:Inhibitory concentration against porcine lens aldose reductase (AR) with DL-glyceraldehyde as the substrateMore data for this Ligand-Target Pair
In DepthDetails Article
TargetAldo-keto reductase family 1 member B1(Sus scrofa)
TBA

Curated by ChEMBL
LigandPNGBDBM50289629(CHEMBL47646 | [3-Oxo-4-(4,5,7-trifluoro-benzothiaz...)
Affinity DataIC50:  9.5nMAssay Description:Inhibitory concentration against porcine lens aldose reductase (AR) with DL-glyceraldehyde as the substrateMore data for this Ligand-Target Pair
In DepthDetails Article
TargetAldo-keto reductase family 1 member B1(Sus scrofa)
TBA

Curated by ChEMBL
LigandPNGBDBM50289612(CHEMBL46170 | [3-Methyl-5-(4,5,7-trifluoro-benzoth...)
Affinity DataIC50:  9.60nMAssay Description:Inhibitory concentration against porcine lens aldose reductase (AR) with DL-glyceraldehyde as the substrateMore data for this Ligand-Target Pair
In DepthDetails Article
TargetAldo-keto reductase family 1 member B1(Sus scrofa)
TBA

Curated by ChEMBL
LigandPNGBDBM50289625(CHEMBL43995 | {Benzyl-[3-(4,5,7-trifluoro-benzothi...)
Affinity DataIC50:  9.70nMAssay Description:Inhibitory concentration against porcine lens aldose reductase (AR) with DL-glyceraldehyde as the substrateMore data for this Ligand-Target Pair
In DepthDetails Article
TargetAldo-keto reductase family 1 member B1(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50563408(CHEMBL4743085)
Affinity DataIC50:  9.70nMAssay Description:Inhibition of Wistar rat lens ALR2 assessed as reduction in NADPH oxidation using D,L-glyceraldehyde and NADPH as substrate preincubated for 10 mins ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM16452((4-oxo-3-{[5-(trifluoromethyl)-1,3-benzothiazol-2-...)
Affinity DataIC50:  10nMAssay Description:Compound was tested for the inhibition of the human placental aldose reductase using the substrate as glyceraldehyde.More data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member B1(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50049730(2-(5-(2-methyl-3-phenylallylidene)-4-oxo-2-thioxot...)
Affinity DataIC50:  10nMAssay Description:Inhibition of crude aldose reductase of rat lensMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50563399(CHEMBL4749891)
Affinity DataIC50:  11nMAssay Description:Inhibition of Wistar rat lens ALR2 assessed as reduction in NADPH oxidation using D,L-glyceraldehyde and NADPH as substrate preincubated for 10 mins ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50056534(CHEMBL162697 | [3-(4-Chloro-benzothiazol-2-ylmethy...)
Affinity DataIC50:  11nMAssay Description:Inhibitory activity against rat lens aldose reductase(AR).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Sus scrofa)
TBA

Curated by ChEMBL
LigandPNGBDBM50289620(CHEMBL442690 | {Methyl-[3-(4,5,7-trifluoro-benzoth...)
Affinity DataIC50:  11nMAssay Description:Inhibitory concentration against porcine lens aldose reductase (AR) with DL-glyceraldehyde as the substrateMore data for this Ligand-Target Pair
In DepthDetails Article
TargetAldo-keto reductase family 1 member B1(Sus scrofa)
TBA

Curated by ChEMBL
LigandPNGBDBM50289615(CHEMBL45290 | [3-Iodo-5-(4,5,7-trifluoro-benzothia...)
Affinity DataIC50:  11nMAssay Description:Inhibitory concentration against porcine lens aldose reductase (AR) with DL-glyceraldehyde as the substrateMore data for this Ligand-Target Pair
In DepthDetails Article
TargetAldo-keto reductase family 1 member B1(Sus scrofa)
TBA

Curated by ChEMBL
LigandPNGBDBM50289619(CHEMBL542104 | [3-Dimethylamino-5-(4,5,7-trifluoro...)
Affinity DataIC50:  12nMAssay Description:Inhibitory concentration against porcine lens aldose reductase (AR) with DL-glyceraldehyde as the substrateMore data for this Ligand-Target Pair
In DepthDetails Article
TargetAldo-keto reductase family 1 member B1(Sus scrofa)
TBA

Curated by ChEMBL
LigandPNGBDBM16496(2-{3-[(4-bromo-2-fluorophenyl)methyl]-7-chloro-2,4...)
Affinity DataIC50:  12nMAssay Description:Inhibitory concentration against porcine lens aldose reductase (AR) with DL-glyceraldehyde as the substrateMore data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member B1(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50056531(CHEMBL161043 | [3-(4-Chloro-benzothiazol-2-ylmethy...)
Affinity DataIC50:  12nMAssay Description:Inhibitory activity against rat lens aldose reductase(AR).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50451729(CHEMBL4206601)
Affinity DataIC50:  13nMAssay Description:Inhibition of ALR2 in Wistar rat eye lens assessed as reduction in NADPH consumption preincubated for 1 min followed by D,L-glyceraldehyde addition m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50451734(CHEMBL4219003)
Affinity DataIC50:  13nMAssay Description:Inhibition of ALR2 in Wistar rat eye lens assessed as reduction in NADPH consumption preincubated for 1 min followed by D,L-glyceraldehyde addition m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50049730(2-(5-(2-methyl-3-phenylallylidene)-4-oxo-2-thioxot...)
Affinity DataIC50:  13nMAssay Description:Inhibitory activity measured against rat lens aldose reductase using 3-pyridinecarboxaldehyde as substrateChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50451729(CHEMBL4206601)
Affinity DataIC50:  13nMAssay Description:Inhibition of ALR2 in Wistar rat eye lens assessed as reduction in NADPH consumption preincubated for 1 min followed by D,L-glyceraldehyde addition m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Sus scrofa)
TBA

Curated by ChEMBL
LigandPNGBDBM50289623(CHEMBL296769 | {Methyl-[3-(4,5,7-trifluoro-benzoth...)
Affinity DataIC50:  13nMAssay Description:Inhibitory concentration against porcine lens aldose reductase (AR) with DL-glyceraldehyde as the substrateMore data for this Ligand-Target Pair
In DepthDetails Article
TargetAldo-keto reductase family 1 member B1(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50451734(CHEMBL4219003)
Affinity DataIC50:  13nMAssay Description:Inhibition of ALR2 in Wistar rat eye lens assessed as reduction in NADPH consumption preincubated for 1 min followed by D,L-glyceraldehyde addition m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50056540(CHEMBL159413 | [3-(5-Chloro-benzothiazol-2-ylmethy...)
Affinity DataIC50:  15nMAssay Description:Inhibitory activity against rat lens aldose reductase(AR).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Sus scrofa)
TBA

Curated by ChEMBL
LigandPNGBDBM50067407((3R)-2'-(4-bromo-2-fluorobenzyl)-1'H,2H,5H-spiro[p...)
Affinity DataIC50:  15nMAssay Description:In vitro inhibitory activity against aldose reductase in porcine lens.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Sus scrofa)
TBA

Curated by ChEMBL
LigandPNGBDBM16314(2-{[6-methoxy-5-(trifluoromethyl)naphthalen-1-yl]-...)
Affinity DataIC50:  15nMAssay Description:In vitro inhibitory activity against aldose reductase in porcine lens.More data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member B1(Sus scrofa)
TBA

Curated by ChEMBL
LigandPNGBDBM16314(2-{[6-methoxy-5-(trifluoromethyl)naphthalen-1-yl]-...)
Affinity DataIC50:  16nMAssay Description:Inhibitory concentration against porcine lens aldose reductase (AR) with DL-glyceraldehyde as the substrateMore data for this Ligand-Target Pair
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